Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching–effacing bacteria
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چکیده
منابع مشابه
Convenient and rapid removal of detergent from glycolipids in detergent-resistant membrane microdomains.
Although detergents are often essential in protocols, they are usually incompatible with further biochemical analysis. There are several methods for detergent removal, but the procedures are complicated or suffer from sample loss. Here, we describe a convenient and rapid method for detergent removal from sialic acid-containing glycosphingolipids (gangliosides) and neutral glycolipids in deterge...
متن کاملCell wall polysaccharide synthases are located in detergent-resistant membrane microdomains in oomycetes.
The pathways responsible for cell wall polysaccharide biosynthesis are vital in eukaryotic microorganisms. The corresponding synthases are potential targets of inhibitors such as fungicides. Despite their fundamental and economical importance, most polysaccharide synthases are not well characterized, and their molecular mechanisms are poorly understood. With the example of Saprolegnia monoica a...
متن کاملJ . Millán CD 4 segregates into specific detergent - J . Cerny resistant T - cell membrane microdomains
In T cells, glycolipids, glycoproteins attached to the membrane via a glycosylphosphatidylinositol (GPI) anchor, and Src-like tyrosine kinases are highly enriched in a membrane fraction resistant to solubilization by nonionic detergents. We have investigated the distribution of CD4 in T-cell membranes and found that approximately 10% of the CD4 co-receptor is associated with detergent-insoluble...
متن کاملDetergent-Resistant Microdomains Determine the Localization of -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction
-1 receptors (Sig-1Rs) that bind diverse synthetic and endogenous compounds have been implicated in the pathophysiology of several human diseases such as drug addiction, depression, neurodegenerative disorders, pain-related disorders, and cancer. Sig-1Rs were identified recently as novel ligand-operated molecular chaperones. Although Sig-1Rs are predominantly expressed at endoplasmic reticulum ...
متن کاملDetergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction.
Sigma-1 receptors (Sig-1Rs) that bind diverse synthetic and endogenous compounds have been implicated in the pathophysiology of several human diseases such as drug addiction, depression, neurodegenerative disorders, pain-related disorders, and cancer. Sig-1Rs were identified recently as novel ligand-operated molecular chaperones. Although Sig-1Rs are predominantly expressed at endoplasmic retic...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2009
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2009.131